June is Alzheimer’s and Mind Consciousness Month.Promising analysis alert!In case you watch TV or any display in any respect, you’ve in all probability heard of glucagon-like peptide-1 (GLP-1) receptor agonists, or GLP-1 medication. The favored prescription weight-loss medicines assist handle blood sugar and cut back urge for food in folks dwelling with Sort 2 diabetes and weight problems. GLP-1 medication have additionally been related to lowered danger for cardiovascular occasions, kidney occasions and kidney failure. Now, researchers are hoping so as to add Alzheimer’s to the checklist. A current examine discovered that the GLP-1 drug semaglutide (which you will know as Ozempic and Wegovy), might sluggish the event of Alzheimer’s and even stop the situation in folks with Sort 2 diabetes.“That’s a serious discovering, particularly because it was based mostly on real-world well being data from over 1,000,000 folks,” mentioned Babak Tousi, M.D., director of medical trials at Cleveland Clinic’s Lou Ruvo Middle for Mind Well being in Cleveland, Ohio. The examine discovered folks with Sort 2 diabetes who took semaglutide have been considerably much less seemingly — 40% to 70% — to be identified with Alzheimer’s inside three years in comparison with folks taking different diabetes medicines, together with different GLP-1 medication. “It means that semaglutide could also be doing extra than simply controlling blood sugar — it could offer actual mind safety,” Tousi mentioned.Learn: The Skinny on Microdosing GLP-1 Medicine >>How semaglutide impacts mind well being Analysis is ongoing concerning the impact of semaglutide on the mind — and most research contain animals to date — however a rising physique of analysis exhibits that semaglutide might profit cognitive perform in folks with diabetes and/or weight problems by improved reminiscence, studying and general psychological efficiency.One systematic evaluation discovered that semaglutide protected the blood-brain barrier, which is answerable for stopping toxins, pathogens (substances that trigger illness) and different dangerous substances from leaking into the mind.“Semaglutide might calm mind irritation, particularly within the mind’s immune cells referred to as microglia, and assist shield the blood-brain barrier — which acts like a safety guard for the mind,” Tousi mentioned. “It additionally seems to enhance blood circulate, cut back oxidative stress — a sort of harm that builds up within the mind — and help mind cell perform. All of those elements play a job in Alzheimer’s illness.”One other examine discovered that semaglutide reversed the indicators of growing older in key mind cells that assist maintain our mind clear, protected and balanced. “Age can result in these cells appearing up, inflicting irritation within the mind and confusion. Taking semaglutide helped these cells behave like they’d in youthful brains,” Tousi mentioned.Take Our Quiz: How A lot Do You Know About Alzheimer’s Illness? >>Tousi additionally famous that the examine discovered semaglutide prevented the formation of a sort of astrocyte — a mind cell that turns poisonous below stress — that worsens irritation and damages mind tissue, a course of additionally seen in Alzheimer’s illness.That is much like the findings of yet another examine, which famous that semaglutide improved cognitive capabilities in mice by performing a number of features, certainly one of which was lowering the quantity of amyloid plaques within the mind. Amyloid plaques are thought to play a job in Alzheimer’s, and this analysis means that semaglutide might not solely have a job in Alzheimer’s prevention, however can also enhance Alzheimer’s in individuals who have already got it.Semaglutide for folks in danger for Alzheimer’sType 2 diabetes and weight problems are each recognized danger elements for Alzheimer’s illness. However given the current findings in human research, semaglutide could also be useful for anybody in danger for Alzheimer’s illness.“As a result of semaglutide seems to assist cut back irritation and shield the mind, there’s rising curiosity in whether or not it may additionally profit folks with out diabetes, particularly these with early reminiscence considerations or sturdy household historical past of dementia,” Tousi mentioned. “This might sign a future the place a typical diabetes drug performs a giant position in mind well being and even dementia prevention.”That is particularly vital to notice for girls and other people assigned feminine at delivery (AFAB) since Alzheimer’s is extra widespread in girls than males. About 1 in 5 girls will probably be identified with Alzheimer’s illness of their lifetime in comparison with 1 in 10 males. There’s presently no treatment for Alzheimer’s, so developments in therapy choices to handle and stop the illness are essential. Promising new analysis on the horizon There’s hope on the horizon concerning semaglutide’s position in stopping or treating Alzheimer’s illness. The outcomes of the primary large-scale human examine displaying whether or not semaglutide can sluggish Alzheimer’s in folks with early levels of illness — even in folks with out Sort 2 diabetes — will probably be launched in September.Learn: Ought to You Get a Blood Check for Alzheimer’s? >>Tousi mentioned the examine features a sub-study the place spinal fluid is being analyzed to assist uncover how the drug works within the mind. The examine might present clues about semaglutide’s precise mechanism and information future therapies.“It’s additionally value noting Alzheimer’s impacts girls greater than males, and early information hints that semaglutide’s mind advantages could also be even stronger in girls,” Tousi mentioned. “These trials ought to assist make clear that.” From Your Web site ArticlesRelated Articles Across the Internet



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